In the pursuit of better success, new drugs and protocols were developed so as to enable more number of eggs. To get more eggs, ovarian stimulation was warranted. To prevent premature ovulation required the use of GnRH analogue and antagonist injections.
While natural IVF continues to be quite inefficient, Mild IVF can enable a middle path to achieve reasonable pregnancy rates at a cost effective price. Mild IVF is also of benefit to women with lower ovarian reserves who do not respond well to stimulation. In these women, a specially designed protocol using Clomiphene tablets and low doses of FSH/hMG injections. The eggs retrieved are fertilised and frozen. Multiple cycles are usually required to accumulate embryos which are then transferred to enable pregnancy.